About Calcitonin:
Calcitonin is a hormone which is basically related with calcium and phosphorus metabolism. In case of mammals, the major source of Calcitonin comes from Para follicular or C cells of the thyroid gland. However the synthesis is not only restricted to C cells, but is also done in a wide variety of other tissues, including the lung and intestinal tract. In birds, fish and amphibians, calcitonin is secreted from the ultimo brachial glands. Considering the 32 amino acid peptide cleaved from a superior prohormone, there is no doubt regarding the role of Calcitonin. It comprises of single disulfide bond, which is responsible for the amino terminus to presume a ring shape. Alternative splicing of Calcitonin pre-mRNA can give way to mRNA programming calcitonin gene-related peptide. This peptide appears to function in the nervous and vascular systems. The role of calcitonin is very prominent and has been effectively proved when calcitonin receptor has been cloned and shown to be a member of the seven-transmembrane, G protein-coupled receptor family.
Effects of Calcitonin:
There has been diversity in terms of effect which has been credited to calcitonin,. These have surfaced as a response to the pharmacologic dose of the hormone, and their physiologic significance is suspected. In particular, calcitonin has the capability to reduce blood calcium levels in part. In bone Calcitonin calms down the bone resorption by holding back osteoclast activity, a cell type that "digests" bone matrix, thus releasing calcium and phosphorus into blood vessels. In Kidney the calcium and phosphorus are barred from being misplaced in urine by Kidney tubule reabsorption. Calcitonin hampers tubular reabsorption of these two ions, leading to greater than before rates of their loss in urine. There is also a clear indication that there are species differences which serves as and important factor for affecting calcium homeostasis.
Controlling Calcitonin Secretion:
The most outstanding factor controlling calcitonin discharge is the extra cellular absorption of ionized calcium. Prominent blood calcium levels strongly excite calcitonin secretion, and secretion is covered up when the concentration of Calcium falls below normal. There have been other hormones, which have stimulated calcitonin release in various conditions and nervous controls.
Pregnancyxl.com informs you about role of Calcitonin, to know more on the other hormones which play major role in Pregnancy, do keep browsing other pages of the site. Navigate your way through good health!
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