Thyroxine (T4) is a tyrosine-based hormone produced by the thyroid gland. The synthesis of thyroxine requires Iodine as one of its main components. Thyroxine is a major form of thyroid hormone which is present in blood. Besides Thyroxine, triiodothyronine (T3) is another thyroid hormone being produced by the thyroid gland. There is absolutely no doubt regarding the role of thyroxine under any circumstances with respect to the development of human body. The ratio of T4 to T3 production is considered roughly from 20 to 1. The conversion of thyroxine to active T3 (three to four times more potent than T4) is done by deiodinases (5'-iodinase) within cells of the body. These are further processed by decarboxylation and deiodination for the production of iodothyronamine (T1a) and thyronamine (T0a). The role of thyroxine becomes extremely important during the pregnancy stage, when concentration of thyroxine swings to action with sudden rise and drops.
Effect of thyroxine on human body:
The thyronines act on the body to raise the basal metabolic rate, influence protein synthesis and add to the body's sensitivity to catecholamines (such as adrenaline) by progressiveness. The thyroid hormones are indispensable for proper development. It also leads to the differentiation of all cells of the human body. These hormones also normalize protein, fat, and carbohydrate metabolism, influencing the use of energetic compounds by human cells. The role of thyroxine is not only limited to exciting metabolism. Studies have also revealed that numerous physiological and pathological stimuli are potential enough for affecting thyroid hormone synthesis. The thyronamines function by means of some unknown mechanism to restrain neuronal activity. It is important to note that this plays an important role in mammal hibernation cycles and moulting bird behavior. Severe drop in body temperature is one consequence of administering thyronamines.
Role of thyroxine during Pregnancy:
During pregnancy and lactation, it is important to measure concentrations of Plasma thyroxine (T4) at particular times. The distribution of Thyroxine space and secretion rates are actually determined by using 125I-labeled T4 at different stages of lactation and pregnancy. Studies have shown that there is an increase in the Plasma concentrations of T4 during lactation which even reaches a maximum level of 4-5 month after the baby is born. The level remains quite constant for the next 2-3 months. During pregnancy, there is a tendency of Thyroxine concentrations dipping down and again there is a sudden drop during the onset of lactation.
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The role of thyroxine becomes prominent during the early stages of pregnancy and very important for the health of the baby to be born.
Pregnancyxl.com informs you about role of thyroxine, to know more on the other hormones which play major role in Pregnancy, do keep browsing other pages of the site. Navigate your way through good health!
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